Understanding GLP-1 and Its Importance for Weight Loss GLP-1 is a hormone produced in the gut that plays a key role in controlling appetite and blood sugar levels. When you eat, GLP-1 is released to signal fullness, slow stomach emptying, and stimulate insulin secretion. These effects help reduce hunger and improve metabolism. Mounjaro and Wegovy are medications that mimic GLP-1’s effects to help people lose weight by reducing appetite and increasing feelings of fullness. The